Mapp Biopharmaceutical
  • San Diego, CA, USA
  • Full Time

Research Associate

Job #18-10R

Mapp Biopharmaceutical is a small biopharmaceutical company focused on addressing unmet medical needs through the development of life-saving monoclonal antibody (mAb) treatment options to combat a variety of neglected and tropical infectious diseases.  The Research Associate is responsible for managing all aspects of the Nicotiana benthamiana expression system.  This includes producing young, healthy 6-week old plants in the Mapp growth room, managing the bacterial expression vectors, infiltrating these vectors into N. benthamiana plants, purifying the antibodies from these plants using standard protein purification and column chromatography methods.  In addition, sterile, purified mAbs should be aliquoted, stored and data entered into electronic inventory system.

Basic Qualifications:

  • B.S. degree or equivalent in major scientific discipline
  • 1 - 2 years experience with basic laboratory technique and the fundamentals of molecular biology
  • Demonstrated excellence in the following competency areas:
    • Ability to work independently
    • Attention to detail

Responsibilities

  • Grows healthy, disease free 4 6 week old Nicotiana benthamiana plants in a controlled environment growth room on a routine basis
  • Manages all supplies and equipment associated with the growth room / laboratory and the process of plant growth
  • Grows bacterial stocks containing different antibody genes and prepare them for infiltration into benthamiana plants on a routine basis
  • Stores and manages all bacterial stocks in order to foster easy retrieval for use in both expression and QA experiments
  • Infiltrates selected bacterial stocks into benthamiana plants as requested
  • Grows benthamiana plants post infiltration for 7 10 days in the growth room in a manner that promotes optimal plant health
  • Grinds and extracts mAbs from benthamiana leaves following standard protein purification and column chromatography techniques
  • Aliquots mAbs in sterile vials of appropriate size
  • Manages physical and electronic mAb inventory system
  • Maintains detailed records of all experiments performed
  • Updates protocols for each step of process as required
  • Manages all supplies, equipment, and vendors for plant expression process
  • Presents and communicates experimental results to the group effectively

Mapp offers a competitive compensation and benefits package in addition to this exciting and challenging job. You will enjoy a flexible, collaborative and rewarding environment in San Diego, CA. Mapp wants you to join their team and invites you to apply.

No Solicitors, agents or placement agencies please. Mapp utilizes E-Verify. 

Equal Opportunity/Affirmative Action/Disability/Vets Employer - Applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected Veteran status, or any other characteristic protected by applicable federal, state, or local law.

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