Mapp Biopharmaceutical
  • San Diego, CA, USA
  • Full Time

Research Associate II – Req #21-25A

Mapp Biopharmaceutical, Inc. "Mapp" is a San Diego based, innovative biopharmaceutical company focused on addressing unmet medical needs through the development of life-saving monoclonal antibody treatment options to combat a variety of neglected and tropical infectious diseases, and in support of biodefense programs.

The Early Research and Development Group (ERDG) and the Advanced Research and Development Group (ARDG) at Mapp Biopharmaceutical are responsible for the execution of high quality Research and Development activities to ensure the achievement of a robust portfolio with the CMC, Preclinical/Nonclinical (together, "Nonclinical"), Regulatory and Clinical development goals consistent with the product development objectives of Mapp.

The Research Associate II will work in the ERDG which is responsible for isolating novel antibodies that may be used in future drug products. The Research Associate II is responsible for performing general laboratory duties as well as supporting ERDG laboratory personnel in meeting their research objectives.

Basic Qualifications:

  • BA or BS or equivalent in a scientific related discipline
  • 2 years relevant scientific research laboratory experience
  • Excellent aseptic technique for cell culture
  • Conceptual understanding of biological research related activities
  • Experience with a variety of cloning techniques (InFusion or Gibson systems, restriction enzyme digestion and ligation, site-directed mutagenesis)
  • Previous experience expressing and purifying recombinant proteins
  • Demonstrated ability to reliably handle multiple samples simultaneously
  • Attention to detail
  • Flexibility and curiosity, with a strong desire to learn new laboratory skills
  • Demonstrated skill in the following areas:
    • Maintains notebooks, databases, and physical banks of all pertinent contributions
    • Ability to work independently and effectively troubleshoot experimental strategies in the laboratory
    • Good general laboratory skills: accurate data collection, analysis, and familiarity with molarity calculations and buffer formulation

Preferred Qualifications:

  • Prior experience operating an AKTA FPLC (Pure or Avant systems) and Cytiva Unicorn software
  • Prior experience with flow cytometry and fluorescence activated single cell sorting (FACS) based techniques
  • Previous experience expressing/purifying/characterizing monoclonal antibodies
  • Ability to independently design and execute cloning workflows, including choice of cloning technique, primer design, plasmid construction and sequence verification
  • Proven ability to handle multiple cell lines in parallel
  • Prior experience working with RNA

Responsibilities

  • Performs molecular biology-related tasks including bacterial culture, DNA purification and quantification, expression plasmid cloning and sequence verification
  • Designs and executes cloning workflows
  • Performs mammalian cell culture
  • Designs and executes basic protein analyses, assays (SDS-PAGE, ELISA, Octet etc.) and troubleshooting
  • Performs protein purification on an AKTA FPLC using a variety of columns (affinity, SEC, IEX) independently
  • Participates in the development of in vitro and cell-based assays to characterize the biological activity of antibodies and antigens
  • Prepares reagents and buffers
  • Maintains detailed records of all experiments performed
  • Develops and supports inventory tracking systems for the Discovery Group
  • Performs general laboratory duties
  • Generates reports and documents as requested
  • Contributes to the publication of scientific discoveries
  • Sets up and organizes lab space (set up lab equipment, lab benches, office furniture, manage waste)
  • Presents effectively and communicates work-related results to supervisor and group

Mapp offers a competitive compensation and benefits package in addition to this exciting and challenging job. You will have the opportunity to work in Mapp's new state-of-the-art San Diego facility. Mapp wants you to join their team and invites you to apply by submitting your information through https://mappbio.applicantpro.com/jobs/.

No Solicitors, agents or placement agencies please. Mapp utilizes E-Verify.

Mapp is an Equal Opportunity/Affirmative Action/Disability/Veterans Employer – Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected Veteran status, or any other characteristic protected by applicable federal, state, or local law.

Mapp Biopharmaceutical
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