Mapp Biopharmaceutical
  • San Diego, CA, USA
  • Full Time


Scientist I – Job #21-29A


Mapp Biopharmaceutical, Inc. "Mapp" is a San Diego based, innovative biopharmaceutical company focused on addressing unmet medical needs through the development of life-saving monoclonal antibody treatment options to combat a variety of neglected and tropical infectious diseases, and in support of biodefense programs.

The Early Research and Development Group (ERDG) and the Advanced Research and Development Group (ARDG) at Mapp Biopharmaceutical are responsible for the execution of high quality Research and Development activities to ensure the achievement of a robust portfolio with the CMC, Preclinical/Nonclinical (together, "Nonclinical"), Regulatory and Clinical development goals consistent with the product development objectives of Mapp.

The Scientist I will work within the Antibody Discovery and Research Group within ERDG which is responsible for isolating novel antibodies that may be used in future drug products. The Scientist I is responsible for executing a variety of protocols related to antibody discovery, as well as supporting ERDG laboratory personnel in meeting their research objectives.

Basic Qualifications:

  • BA/BS or MS in a relevant scientific discipline
  • 10 years of experience with a BA/BS or 7 years of experience with a MS in a research laboratory environment
  • Ability to independently contribute to scientific research programs in the Antibody Discovery and Research Group
  • Demonstrated excellence in the design and cloning of expression vectors for multiple recombinant cell expression systems
  • Prior experience expressing and purifying recombinant proteins
  • Proven ability to reliably manage samples in high-throughput format
  • Prior phage display and panning experience
  • Ability to work independently and effectively troubleshoot experimental strategies in the laboratory
  • Attention to detail and keen scientific observation

Preferred Qualifications:

  • Previous experience with next-generation sequencing
  • Experience operating a robotic liquid handler
  • Experience running Akta FPLCs and GE unicorn software
  • Development of novel technology and/or methodology to increase laboratory capabilities
  • Authorship on multiple scientific publications in respected peer reviewed journals
  • Contributed to the preparation of government grant and/or contract proposals

Responsibilities

  • Designs and executes critical experiments independently
  • Contributes to data and analyses to support writing of publications and grant applications
  • Develops novel technology and/or methodology to increase laboratory capabilities
  • Performs high-throughput/plate-based assays for a variety of platforms reliably, maintaining sample integrity
  • Phage display
  • Builds phage display libraries
  • Develops and executes workflows for phage panning/enrichment
  • Sequences phage of interest
  • Recombinant protein expression and purification from bacteria
  • Optimizes expression constructs for protein stability, solubility and expression levels
  • Familiar with the operation of an AKTA Xpress, AKTA Pure, and/or AKTA Avant FPLC and Cytiva unicorn software
  • Familiar with multiple types of affinity chromatography media and their applications
  • Performs analytical assays
  • UV Spectrophotometry for determining protein concentration
  • Uses a combination of SEC, SDS-PAGE and/or western blots to evaluate protein composition, stability or structural integrity
  • Operates a ForteBio Octet 96 (BLI) for quantitative and/or kinetics-based assays
  • Manages multiple projects concurrently in the laboratory
  • Anticipates and executes experiments to move projects forward without prompting
  • Communicates effectively with and manages collaborating scientists to ensure projects continue to progress efficiently toward deliverables
  • Maintains a detailed and legible record of all experiments performed
  • Presents and communicates experimental results to the group effectively

Mapp offers a competitive compensation and benefits package in addition to this exciting and challenging job. You will have the opportunity to work in Mapp's new state-of-the-art San Diego facility. Mapp wants you to join their team and invites you to apply by submitting your information through https://mappbio.applicantpro.com/jobs/.

No Solicitors, agents or placement agencies please. Mapp utilizes E-Verify.

Mapp is an Equal Opportunity/Affirmative Action/Disability/Veterans Employer – Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected Veteran status, or any other characteristic protected by applicable federal, state, or local law.

Mapp Biopharmaceutical
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